Mitotic membrane turnover: inscribing heart cell fate during division
Dr. Brad Davidson
Abstract: Cell fate decisions can be impacted by trafficking of signal components. Recent studies have overturned the long-held assumption that trafficking is shutdown during mitosis. Thus, mitotic trafficking of signaling components may play a profound, largely unrecognized role in embryonic and stem cell fate. We have gained significant insights regarding the interplay between division and signaling by examining embryonic development in the basal chordate, Ciona intestinalis. The extreme cellular simplicity of Ciona embryos facilitates high-resolution, in vivo analysis of inductive signaling mechanisms. In particular, we focus on Fibroblast Growth Factor (FGF) dependent induction of the heart progenitor lineage. We have found that mitotic redistribution of FGF receptors (FGFRs) promotes differential heart progenitor induction. We are currently investigating the role of mitotic kinases in FGF receptor localization.
Tuesday, Jan. Feb. 9, 12:20 – 1:20 pm, in the Science Lecture Hall
Date & Time
February 9, 2016
12:20 pm-1:20 pm